???????????? ????? ????????? �????????????� ??????? � ???????? ???????????
?????? ???????????? ???? ????? ???????? ????????????????????? ????????? ???????? ???? ?????????? ?????? ?????????. ???? ?????? ???????????? ??????? ?? ??????????? ????????? ?????? ???????. ??????????? ???????????? (remdesivir) ???? ????? ????? ????????? ??????? ??????-19-???? ?????? ???? ???? ???????????? ?????? ????????.
????????????
???? ???????????? ????? ????????????? ????????? ??????? ???????????????. ?????? ????-2 ???? ????? ???.???.?-???? ??? ?????. ??? ???????????????? ??? ?????????????? ??????? ???? ????? ????, ??????????? ??????????? ???.???.?-?? ??????????????? ???.???.? ?????????? (RDRp) ???? ???????????????? ???????? ?????????????????????.
??????????? ?????? 30 ??? ??????? ?????????? !!!
???????? ?????? ?????, ????????? ?? ??????????? ?????????? ?????? ??????????? ????????????. ???? ?????????????? ???? ???????? ??????? ????? ????? ??????????? ???? ???????? ????? ????????? ????????????????.
ucleotide analogue
???.???.?.?? ??????????????? ???.???.? ?????????? ?????????? ???.???.?. ?????? ??????????? ??????????? ??????????????. ???? ???????????? ???? ???? ??????? ??????? ???? ???????? ???????? ???????? ?????????? ??????????? ???????? ??????????????. ???????????? ???? ???? ??????? ???????? ??????????????? ????????? ????? ????????? ???????????. ?????? nucleotide analogue ????? ?????.
?????? ?????????? ???????????? 3 ????????? ?????????????? ????? ???????????.!
??? ???.???.?. ???????????? ???????? ?????????? ???? ????? ???? ?????????????? ???????????????? ???? ?????? ??????????? ????? ????????? ????? ??????????????, ???? ????? ??????????????? ??????????. �Structure of the RNA-dependent RNA polymerase (RDRp) from COVID-19 virus� ????? ?????????????? ?????? ??????????? ??????????????? ????? ????? ?????? ??????-19 ??????????? RDRpk????, ???????????? ????????????? ????? ???????? ??????????? ??????? ????????? ??????????? ???????????????.
???.???.? ?????????? ?????????? ?????????????? ????? ???????. ??????? ???????????????? ????? ????????????? ?????????????. ?????? ???? ?????????????? ????? ???????? ????????. ?????? ?????? ????????? ??????? ???????????? ????????? ??????????? ?????? ????????, ????????? ?????????? ???????????? ??.????????. ????????????? (sofosbuvir) ??????? ???????????? ???? ?????????? ????????? ??????????? ????? ?????? ??.???????? ????????????? ???????? ??????????? ??????????????? ??????????? ?? ???? ???????????? ?????????????????????? ????????????.
??????????????????? ?????????
??????????? ???????? ?????? ???????? ?????? ??????? ????????? ????? ???????????? ??????????? ?????????????. ????? ????????? 16 ?????????????? ?????????? 213 ????????? ???????????? ???????????????????? ??? ??????? ??????? ????????????? ?????????? ??? ????????? 99,690 ????? ??????????? ??????????????? ???????????? ??????? ????????? ?????? ???????? ????? ??????????? ????????? ????????????????.
??????????? ????????? ???? 12 ?????? ????????????? ??????
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